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Chromatin Accessibility Data Sets Show Bias Due to Sequence Specificity of the DNase I Enzyme
BACKGROUND: DNase I is an enzyme which cuts duplex DNA at a rate that depends strongly upon its chromatin environment. In combination with high-throughput sequencing (HTS) technology, it can be used to infer genome-wide landscapes of open chromatin regions. Using this technology, systematic identifi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724795/ https://www.ncbi.nlm.nih.gov/pubmed/23922824 http://dx.doi.org/10.1371/journal.pone.0069853 |