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Chromatin Accessibility Data Sets Show Bias Due to Sequence Specificity of the DNase I Enzyme

BACKGROUND: DNase I is an enzyme which cuts duplex DNA at a rate that depends strongly upon its chromatin environment. In combination with high-throughput sequencing (HTS) technology, it can be used to infer genome-wide landscapes of open chromatin regions. Using this technology, systematic identifi...

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Detalles Bibliográficos
Autores principales:	Koohy, Hashem, Down, Thomas A., Hubbard, Tim J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724795/ https://www.ncbi.nlm.nih.gov/pubmed/23922824 http://dx.doi.org/10.1371/journal.pone.0069853

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