SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition

Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) used for the treatment of cutaneous T cell lymphoma (CTCL) and under consideration for other indications. In vivo studies suggest reducing HDAC function can enhance synaptic function and memory, raising the possib...

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Detalles Bibliográficos
Autores principales: Hanson, Jesse E., La, Hank, Plise, Emile, Chen, Yung-Hsiang, Ding, Xiao, Hanania, Taleen, Sabath, Emily V., Alexandrov, Vadim, Brunner, Dani, Leahy, Emer, Steiner, Pascal, Liu, Lichuan, Scearce-Levie, Kimberly, Zhou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724849/
https://www.ncbi.nlm.nih.gov/pubmed/23922875
http://dx.doi.org/10.1371/journal.pone.0069964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724849/
https://www.ncbi.nlm.nih.gov/pubmed/23922875
http://dx.doi.org/10.1371/journal.pone.0069964

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