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SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition
Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) used for the treatment of cutaneous T cell lymphoma (CTCL) and under consideration for other indications. In vivo studies suggest reducing HDAC function can enhance synaptic function and memory, raising the possib...
Autores principales: | Hanson, Jesse E., La, Hank, Plise, Emile, Chen, Yung-Hsiang, Ding, Xiao, Hanania, Taleen, Sabath, Emily V., Alexandrov, Vadim, Brunner, Dani, Leahy, Emer, Steiner, Pascal, Liu, Lichuan, Scearce-Levie, Kimberly, Zhou, Qiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724849/ https://www.ncbi.nlm.nih.gov/pubmed/23922875 http://dx.doi.org/10.1371/journal.pone.0069964 |
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