Mechanistic studies of an unprecedented enzyme-catalyzed 1,2-phosphono migration reaction

(S)-2-Hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-heme iron-dependent enzyme(1,2,3) responsible for the last step in the biosynthesis of the clinically useful antibiotic fosfomycin(4). Enzymes of this class typically catalyze oxygenation reactions that proceed via the...

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Detalles Bibliográficos
Autores principales: Chang, Wei-chen, Dey, Mishtu, Liu, Pinghua, Mansoorabadi, Steven O., Moon, Sung-Ju, Zhao, Zongbao K., Drennan, Catherine L., Liu, Hung-wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725809/
https://www.ncbi.nlm.nih.gov/pubmed/23552950
http://dx.doi.org/10.1038/nature11998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725809/
https://www.ncbi.nlm.nih.gov/pubmed/23552950
http://dx.doi.org/10.1038/nature11998

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