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Screened selection design for randomised phase II oncology trials: an example in chronic lymphocytic leukaemia

BACKGROUND: As there are limited patients for chronic lymphocytic leukaemia trials, it is important that statistical methodologies in Phase II efficiently select regimens for subsequent evaluation in larger-scale Phase III trials. METHODS: We propose the screened selection design (SSD), which is a p...

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Detalles Bibliográficos
Autores principales: Yap, Christina, Pettitt, Andrew, Billingham, Lucinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726070/
https://www.ncbi.nlm.nih.gov/pubmed/23819695
http://dx.doi.org/10.1186/1471-2288-13-87