Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach

BACKGROUND: Recent reports suggest the role of nonsynonymous single nucleotide polymorphisms (nsSNPs) in cyclin-dependent kinase 7 (CDK7) gene associated with defect in the DNA repair mechanism that may contribute to cancer risk. Among the various inhibitors developed so far, flavopiridol proved to...

Descripción completa

Detalles Bibliográficos
Autores principales: George Priya Doss, C, Nagasundaram, N, Chakraborty, Chiranjib, Chen, Luonan, Zhu, Hailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726351/
https://www.ncbi.nlm.nih.gov/pubmed/23561625
http://dx.doi.org/10.1186/1479-7364-7-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726351/
https://www.ncbi.nlm.nih.gov/pubmed/23561625
http://dx.doi.org/10.1186/1479-7364-7-10

Ejemplares similares