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Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach

BACKGROUND: Recent reports suggest the role of nonsynonymous single nucleotide polymorphisms (nsSNPs) in cyclin-dependent kinase 7 (CDK7) gene associated with defect in the DNA repair mechanism that may contribute to cancer risk. Among the various inhibitors developed so far, flavopiridol proved to...

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Detalles Bibliográficos
Autores principales:	George Priya Doss, C, Nagasundaram, N, Chakraborty, Chiranjib, Chen, Luonan, Zhu, Hailong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726351/ https://www.ncbi.nlm.nih.gov/pubmed/23561625 http://dx.doi.org/10.1186/1479-7364-7-10

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