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Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) has a biased nucleotide composition different from human genes. This raises the question of how evolution has chosen the nucleotide sequence of HIV-1 that is observed today, or to what extent the actual encoding contributes to virus replication...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726367/ https://www.ncbi.nlm.nih.gov/pubmed/23885919 http://dx.doi.org/10.1186/1742-4690-10-78 |