Asymmetric kinase dimer formation is crucial for the activation of oncogenic EGFRvIII but not for ERBB3 phosphorylation

BACKGROUND: Formation of asymmetric kinase dimers is required for wt-EGFR activation upon ligand stimulation. The role of receptor dimerization in oncogenic EGFRvIII mutant activation is not completely understood and the molecular details of EGFRvIII interactions within homo-dimers and hetero-dimers...

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Detalles Bibliográficos
Autores principales: Kancha, Rama Krishna, von Bubnoff, Nikolas, Duyster, Justus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726407/
https://www.ncbi.nlm.nih.gov/pubmed/23758840
http://dx.doi.org/10.1186/1478-811X-11-39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726407/
https://www.ncbi.nlm.nih.gov/pubmed/23758840
http://dx.doi.org/10.1186/1478-811X-11-39

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