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Cisplatin and Doxorubicin Induce Distinct Mechanisms of Ovarian Follicle Loss; Imatinib Provides Selective Protection Only against Cisplatin
PURPOSE: Chemotherapy treatment in premenopausal women has been linked to ovarian follicle loss and premature ovarian failure; the exact mechanism by which this occurs is uncertain. Here, two commonly used chemotherapeutic agents (cisplatin and doxorubicin) were added to a mouse ovary culture system...
Autores principales: | Morgan, Stephanie, Lopes, Federica, Gourley, Charlie, Anderson, Richard A., Spears, Norah |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726485/ https://www.ncbi.nlm.nih.gov/pubmed/23922929 http://dx.doi.org/10.1371/journal.pone.0070117 |
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