Cargando…

Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension

OBJECTIVE: This randomized crossover trial assessed the effects of 5 weeks of consuming low-fat dairy (one serving/day each of 1% fluid milk, low-fat cheese, and low-fat yogurt) versus nondairy products (one serving/day each of apple juice, pretzels, and cereal bar) on systolic and diastolic blood p...

Descripción completa

Detalles Bibliográficos
Autores principales: Maki, Kevin C, Rains, Tia M, Schild, Arianne L, Dicklin, Mary R, Park, Keigan M, Lawless, Andrea L, Kelley, Kathleen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726585/
https://www.ncbi.nlm.nih.gov/pubmed/23901280
http://dx.doi.org/10.2147/VHRM.S45684
_version_ 1782278666509615104
author Maki, Kevin C
Rains, Tia M
Schild, Arianne L
Dicklin, Mary R
Park, Keigan M
Lawless, Andrea L
Kelley, Kathleen M
author_facet Maki, Kevin C
Rains, Tia M
Schild, Arianne L
Dicklin, Mary R
Park, Keigan M
Lawless, Andrea L
Kelley, Kathleen M
author_sort Maki, Kevin C
collection PubMed
description OBJECTIVE: This randomized crossover trial assessed the effects of 5 weeks of consuming low-fat dairy (one serving/day each of 1% fluid milk, low-fat cheese, and low-fat yogurt) versus nondairy products (one serving/day each of apple juice, pretzels, and cereal bar) on systolic and diastolic blood pressures (SBP and DBP), vascular function (reactive hyperemia index [RHI] and augmentation index), and plasma lipids. METHODS: Patients were 62 men and women (mean age 54.5 years, body mass index 29.2 kg/m(2)) with prehypertension or stage 1 hypertension (mean resting SBP/DBP 129.8 mmHg/80.8 mmHg) while not receiving antihypertensive medications. A standard breakfast meal challenge including two servings of study products was administered at the end of each treatment period. RESULTS: Dairy and nondairy treatments did not produce significantly different mean SBP or DBP in the resting postprandial state or from premeal to 3.5 hours postmeal (SBP, 126.3 mmHg versus 124.9 mmHg; DBP, 76.5 mmHg versus 75.7 mmHg), premeal (2.35 versus 2.20) or 2 hours postmeal (2.33 versus 2.30) RHI, and premeal (22.5 versus 23.8) or 2 hours postmeal (12.4 versus 13.2) augmentation index. Among subjects with endothelial dysfunction (RHI ≤ 1.67; n = 14) during the control treatment, premeal RHI was significantly higher in the dairy versus nondairy condition (2.32 versus 1.50, P = 0.002). Fasting lipoprotein lipid values were not significantly different between treatments overall, or in subgroup analyses. CONCLUSION: No significant effects of consuming low-fat dairy products, compared with low-fat nondairy products, were observed for blood pressures, measures of vascular function, or lipid variables in the overall sample, but results from subgroup analyses were consistent with the hypothesis that dairy foods might improve RHI in those with endothelial dysfunction.
format Online
Article
Text
id pubmed-3726585
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-37265852013-07-30 Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension Maki, Kevin C Rains, Tia M Schild, Arianne L Dicklin, Mary R Park, Keigan M Lawless, Andrea L Kelley, Kathleen M Vasc Health Risk Manag Original Research OBJECTIVE: This randomized crossover trial assessed the effects of 5 weeks of consuming low-fat dairy (one serving/day each of 1% fluid milk, low-fat cheese, and low-fat yogurt) versus nondairy products (one serving/day each of apple juice, pretzels, and cereal bar) on systolic and diastolic blood pressures (SBP and DBP), vascular function (reactive hyperemia index [RHI] and augmentation index), and plasma lipids. METHODS: Patients were 62 men and women (mean age 54.5 years, body mass index 29.2 kg/m(2)) with prehypertension or stage 1 hypertension (mean resting SBP/DBP 129.8 mmHg/80.8 mmHg) while not receiving antihypertensive medications. A standard breakfast meal challenge including two servings of study products was administered at the end of each treatment period. RESULTS: Dairy and nondairy treatments did not produce significantly different mean SBP or DBP in the resting postprandial state or from premeal to 3.5 hours postmeal (SBP, 126.3 mmHg versus 124.9 mmHg; DBP, 76.5 mmHg versus 75.7 mmHg), premeal (2.35 versus 2.20) or 2 hours postmeal (2.33 versus 2.30) RHI, and premeal (22.5 versus 23.8) or 2 hours postmeal (12.4 versus 13.2) augmentation index. Among subjects with endothelial dysfunction (RHI ≤ 1.67; n = 14) during the control treatment, premeal RHI was significantly higher in the dairy versus nondairy condition (2.32 versus 1.50, P = 0.002). Fasting lipoprotein lipid values were not significantly different between treatments overall, or in subgroup analyses. CONCLUSION: No significant effects of consuming low-fat dairy products, compared with low-fat nondairy products, were observed for blood pressures, measures of vascular function, or lipid variables in the overall sample, but results from subgroup analyses were consistent with the hypothesis that dairy foods might improve RHI in those with endothelial dysfunction. Dove Medical Press 2013 2013-07-23 /pmc/articles/PMC3726585/ /pubmed/23901280 http://dx.doi.org/10.2147/VHRM.S45684 Text en © 2013 Maki et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Maki, Kevin C
Rains, Tia M
Schild, Arianne L
Dicklin, Mary R
Park, Keigan M
Lawless, Andrea L
Kelley, Kathleen M
Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension
title Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension
title_full Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension
title_fullStr Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension
title_full_unstemmed Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension
title_short Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension
title_sort effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726585/
https://www.ncbi.nlm.nih.gov/pubmed/23901280
http://dx.doi.org/10.2147/VHRM.S45684
work_keys_str_mv AT makikevinc effectsoflowfatdairyintakeonbloodpressureendothelialfunctionandlipoproteinlipidsinsubjectswithprehypertensionorstage1hypertension
AT rainstiam effectsoflowfatdairyintakeonbloodpressureendothelialfunctionandlipoproteinlipidsinsubjectswithprehypertensionorstage1hypertension
AT schildariannel effectsoflowfatdairyintakeonbloodpressureendothelialfunctionandlipoproteinlipidsinsubjectswithprehypertensionorstage1hypertension
AT dicklinmaryr effectsoflowfatdairyintakeonbloodpressureendothelialfunctionandlipoproteinlipidsinsubjectswithprehypertensionorstage1hypertension
AT parkkeiganm effectsoflowfatdairyintakeonbloodpressureendothelialfunctionandlipoproteinlipidsinsubjectswithprehypertensionorstage1hypertension
AT lawlessandreal effectsoflowfatdairyintakeonbloodpressureendothelialfunctionandlipoproteinlipidsinsubjectswithprehypertensionorstage1hypertension
AT kelleykathleenm effectsoflowfatdairyintakeonbloodpressureendothelialfunctionandlipoproteinlipidsinsubjectswithprehypertensionorstage1hypertension