Cargando…

A Metabolically-Stabilized Phosphonate Analog of Lysophosphatidic Acid Attenuates Collagen-Induced Arthritis

Rheumatoid arthritis (RA) is a destructive arthropathy with systemic manifestations, characterized by chronic synovial inflammation. Under the influence of the pro-inflammatory milieu synovial fibroblasts (SFs), the main effector cells in disease pathogenesis become activated and hyperplastic while...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nikitopoulou, Ioanna, Kaffe, Eleanna, Sevastou, Ioanna, Sirioti, Ivi, Samiotaki, Martina, Madan, Damian, Prestwich, Glenn D., Aidinis, Vassilis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726599/ https://www.ncbi.nlm.nih.gov/pubmed/23923032 http://dx.doi.org/10.1371/journal.pone.0070941

Ejemplares similares

Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer
por: Kaffe, Eleanna, et al.
Publicado: (2019)

Genetic deletion of Autotaxin from CD11b(+) cells decreases the severity of experimental autoimmune encephalomyelitis
por: Ninou, Ioanna, et al.
Publicado: (2020)

Autotaxin and Endotoxin-Induced Acute Lung Injury
por: Mouratis, Marios-Angelos, et al.
Publicado: (2015)

The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer
por: Magkrioti, Christiana, et al.
Publicado: (2023)

Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis
por: Nikitopoulou, Ioanna, et al.
Publicado: (2012)

A role for bronchial epithelial autotaxin in ventilator-induced lung injury
por: Nikitopoulou, Ioanna, et al.
Publicado: (2021)

Orotracheal treprostinil administration attenuates bleomycin-induced lung injury, vascular remodeling, and fibrosis in mice
por: Nikitopoulou, Ioanna, et al.
Publicado: (2019)

The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life
por: Katsifa, Aggeliki, et al.
Publicado: (2015)

Autotaxin Has a Negative Role in Systemic Inflammation
por: Nikitopoulou, Ioanna, et al.
Publicado: (2022)

Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors
por: Magkrioti, Christiana, et al.
Publicado: (2020)

Autotaxin Activity in Chronic Subdural Hematoma: A Prospective Clinical Study
por: Kalamatianos, Theodosis, et al.
Publicado: (2022)

Lysophosphatidic Acid Is a Proinflammatory Stimulus of Renal Tubular Epithelial Cells
por: Magkrioti, Christiana, et al.
Publicado: (2022)

Autotaxin in Pathophysiology and Pulmonary Fibrosis
por: Ninou, Ioanna, et al.
Publicado: (2018)

Increased Levels of Galectin-3 in Critical COVID-19
por: Nikitopoulou, Ioanna, et al.
Publicado: (2023)

Bleomycin Revisited: A Direct Comparison of the Intratracheal Micro-Spraying and the Oropharyngeal Aspiration Routes of Bleomycin Administration in Mice
por: Barbayianni, Ilianna, et al.
Publicado: (2018)

Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
por: Roy, Subhadeep, et al.
Publicado: (2013)

The Anti-Tumoral Potential of Phosphonate Analog of Sulforaphane in Zebrafish Xenograft Model
por: Rudzinska-Radecka, Magdalena, et al.
Publicado: (2021)

Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model
por: Joshi, Lisha, et al.
Publicado: (2021)

Dual Action of Lysophosphatidate-Functionalised Titanium: Interactions with Human (MG63) Osteoblasts and Methicillin Resistant Staphylococcus aureus
por: Skindersoe, Mette Elena, et al.
Publicado: (2015)

Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing
por: Sevastou, Ioanna, et al.
Publicado: (2016)

Selective Esterification of Phosphonic Acids †
por: Trzepizur, Damian, et al.
Publicado: (2021)

Increased Autotaxin Levels in Severe COVID-19, Correlating with IL-6 Levels, Endothelial Dysfunction Biomarkers, and Impaired Functions of Dendritic Cells
por: Nikitopoulou, Ioanna, et al.
Publicado: (2021)

Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation
por: Zhang, Chunxiang, et al.
Publicado: (2004)

Correction: Dual Action of Lysophosphatidate-Functionalised Titanium: Interactions with Human (MG63) Osteoblasts and Methicillin Resistant Staphylococcus aureus
por: Skindersoe, Mette Elena, et al.
Publicado: (2016)

MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia
por: Plastira, Ioanna, et al.
Publicado: (2020)

Phosphonate Analogs of 2-Oxoglutarate Perturb Metabolism and Gene Expression in Illuminated Arabidopsis Leaves
por: Araújo, Wagner L., et al.
Publicado: (2012)

Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates
por: Artiukhov, Artem V., et al.
Publicado: (2021)

ENPP2 Promoter Methylation Correlates with Decreased Gene Expression in Breast Cancer: Implementation as a Liquid Biopsy Biomarker
por: Panagopoulou, Maria, et al.
Publicado: (2022)

Increase of HO-1 Expression in Critically Ill COVID-19 Patients Is Associated with Poor Prognosis and Outcome
por: Detsika, Maria G., et al.
Publicado: (2022)

Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects
por: Krečmerová, Marcela, et al.
Publicado: (2022)

Phosphonic Acid Analogs of Fluorophenylalanines as Inhibitors of Human and Porcine Aminopeptidases N: Validation of the Importance of the Substitution of the Aromatic Ring
por: Wanat, Weronika, et al.
Publicado: (2020)

Phosphonate–Phosphinate Rearrangement
por: Qian, Renzhe, et al.
Publicado: (2014)

Direct Synthesis of Phosphonates and α-Amino-phosphonates from 1,3-Benzoxazines
por: Salgado-Escobar, Oscar, et al.
Publicado: (2019)

The McKenna reaction – avoiding side reactions in phosphonate deprotection
por: Justyna, Katarzyna, et al.
Publicado: (2020)

Non-Invasive Imaging of Tumors by Monitoring Autotaxin Activity Using an Enzyme-Activated Near-Infrared Fluorogenic Substrate
por: Madan, Damian, et al.
Publicado: (2013)

Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia
por: Joshi, Lisha, et al.
Publicado: (2021)

Lysophosphatidic Acid Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury in the Immature Hearts of Rats
por: Chen, Haibo, et al.
Publicado: (2017)

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model
por: Axelsson Raja, Anna, et al.
Publicado: (2022)

2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition
por: Fukasawa, Keiko, et al.
Publicado: (2021)

Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis
por: Yang, Bicheng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_stcmiedthm15hvofks8ek7pkot