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Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn
FcRn, a non-classical MHCI molecule, transports IgG from mother to young and regulates the rate of IgG degradation throughout life. Brambell proposed a mechanism that unified these two functions, saying that IgG was pinocytosed nonspecifically by the cell into an FcRn-expressing endosome, where, at...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726603/ https://www.ncbi.nlm.nih.gov/pubmed/23923029 http://dx.doi.org/10.1371/journal.pone.0070863 |
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author | Mohanty, Sudhasri Kim, Jonghan Ganesan, Latha P. Phillips, Gary S. Robinson, John M. Anderson, Clark L. |
author_facet | Mohanty, Sudhasri Kim, Jonghan Ganesan, Latha P. Phillips, Gary S. Robinson, John M. Anderson, Clark L. |
author_sort | Mohanty, Sudhasri |
collection | PubMed |
description | FcRn, a non-classical MHCI molecule, transports IgG from mother to young and regulates the rate of IgG degradation throughout life. Brambell proposed a mechanism that unified these two functions, saying that IgG was pinocytosed nonspecifically by the cell into an FcRn-expressing endosome, where, at low pH, it bound to FcRn and was exocytosed. This theory was immediately challenged by claims that FcRn specificity for ligand could be conferred at the cell surface in neonatal jejunum. Assessing Brambell's hypothesis we found abundant nonspecifically endocytosed IgG present in the cytoplasm of FcRn(−/−) enterocytes. Further, IgG was present in the intercellular clefts and the cores of FcRn(+/+) but not FcRn(−/−) jejunum. FcRn specificity for ligand could be determined within the cell. |
format | Online Article Text |
id | pubmed-3726603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37266032013-08-06 Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn Mohanty, Sudhasri Kim, Jonghan Ganesan, Latha P. Phillips, Gary S. Robinson, John M. Anderson, Clark L. PLoS One Research Article FcRn, a non-classical MHCI molecule, transports IgG from mother to young and regulates the rate of IgG degradation throughout life. Brambell proposed a mechanism that unified these two functions, saying that IgG was pinocytosed nonspecifically by the cell into an FcRn-expressing endosome, where, at low pH, it bound to FcRn and was exocytosed. This theory was immediately challenged by claims that FcRn specificity for ligand could be conferred at the cell surface in neonatal jejunum. Assessing Brambell's hypothesis we found abundant nonspecifically endocytosed IgG present in the cytoplasm of FcRn(−/−) enterocytes. Further, IgG was present in the intercellular clefts and the cores of FcRn(+/+) but not FcRn(−/−) jejunum. FcRn specificity for ligand could be determined within the cell. Public Library of Science 2013-07-29 /pmc/articles/PMC3726603/ /pubmed/23923029 http://dx.doi.org/10.1371/journal.pone.0070863 Text en © 2013 Mohanty et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Mohanty, Sudhasri Kim, Jonghan Ganesan, Latha P. Phillips, Gary S. Robinson, John M. Anderson, Clark L. Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn |
title | Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn |
title_full | Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn |
title_fullStr | Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn |
title_full_unstemmed | Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn |
title_short | Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn |
title_sort | abundant intracellular igg in enterocytes and endoderm lacking fcrn |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726603/ https://www.ncbi.nlm.nih.gov/pubmed/23923029 http://dx.doi.org/10.1371/journal.pone.0070863 |
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