Telomerase Contributes to Fludarabine Resistance in Primary Human Leukemic Lymphocytes

We report that Imetelstat, a telomerase inhibitor that binds to the RNA component of telomerase (hTR), can sensitize primary CLL lymphocytes to fludarabine in vitro. This effect was observed in lymphocytes from clinically resistant cases and with cytogenetic abnormalities associated with bad prognos...

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Detalles Bibliográficos
Autores principales: Shawi, May, Chu, Tsz Wai, Martinez-Marignac, Veronica, Yu, Y., Gryaznov, Sergei M., Johnston, James B., Lees-Miller, Susan P., Assouline, Sarit E., Autexier, Chantal, Aloyz, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726637/
https://www.ncbi.nlm.nih.gov/pubmed/23922990
http://dx.doi.org/10.1371/journal.pone.0070428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726637/
https://www.ncbi.nlm.nih.gov/pubmed/23922990
http://dx.doi.org/10.1371/journal.pone.0070428

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