Cargando…

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

Age-related macular degeneration (AMD) is the most common reason of visual impairment in the elderly in the Western countries. The degeneration of retinal pigment epithelial cells (RPE) causes secondarily adverse effects on neural retina leading to visual loss. The aging characteristics of the RPE i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Viiri, Johanna, Amadio, Marialaura, Marchesi, Nicoletta, Hyttinen, Juha M. T., Kivinen, Niko, Sironen, Reijo, Rilla, Kirsi, Akhtar, Saeed, Provenzani, Alessandro, D'Agostino, Vito Giuseppe, Govoni, Stefano, Pascale, Alessia, Agostini, Hansjurgen, Petrovski, Goran, Salminen, Antero, Kaarniranta, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726683/ https://www.ncbi.nlm.nih.gov/pubmed/23922739 http://dx.doi.org/10.1371/journal.pone.0069563

Ejemplares similares

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38(MAPK), and JNK Kinase Pathways
por: Marchesi, Nicoletta, et al.
Publicado: (2018)

Deficiency of the RNA-binding protein ELAVL1/HuR leads to the failure of endogenous and exogenous neuroprotection of retinal ganglion cells
por: Pacwa, Anna, et al.
Publicado: (2023)

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells
por: Viiri, Johanna, et al.
Publicado: (2010)

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
por: Palomo-Irigoyen, Marta, et al.
Publicado: (2020)

HuR (Elavl1) and HuB (Elavl2) Stabilize Matrix Metalloproteinase-9 mRNA During Seizure-Induced Mmp-9 Expression in Neurons
por: Zybura-Broda, Katarzyna, et al.
Publicado: (2018)

The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response
por: Diaz-Muñoz, Manuel D., et al.
Publicado: (2015)

Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis
por: García-Domínguez, Daniel J., et al.
Publicado: (2011)

RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification
por: Hutchins, Erica J, et al.
Publicado: (2022)

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function
por: D’Agostino, Vito Giuseppe, et al.
Publicado: (2015)

Altered Regulation of ELAVL1/HuR in HLA-B27–Expressing U937 Monocytic Cells
por: Sahlberg, Anna S., et al.
Publicado: (2013)

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells
por: Ryhänen, Tuomas, et al.
Publicado: (2011)

MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats
por: Ferrigno, Andrea, et al.
Publicado: (2023)

The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages
por: Chi, Mai Nguyen, et al.
Publicado: (2011)

PLK1-ELAVL1/HuR-miR-122 signaling facilitates hepatitis C virus proliferation
por: Seo, Yoona, et al.
Publicado: (2022)

Deletion of the mRNA stability factor ELAVL1 (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity
por: McCarthy, Grace A, et al.
Publicado: (2023)

Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence
por: Yi, Jie, et al.
Publicado: (2010)

Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR
por: Battaglia-Hsu, Shyue-Fang, et al.
Publicado: (2018)

m(6)A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR
por: Kong, Zhe, et al.
Publicado: (2023)

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells
por: Ryhänen, Tuomas, et al.
Publicado: (2009)

Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome
por: Hoffman, Olivia, et al.
Publicado: (2017)

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
por: Salminen, Antero, et al.
Publicado: (2011)

Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells
por: Latorre, Elisa, et al.
Publicado: (2012)

A Novel High Throughput Biochemical Assay to Evaluate the HuR Protein-RNA Complex Formation
por: D’Agostino, Vito G., et al.
Publicado: (2013)

Regulation of HuR structure and function by dihydrotanshinone-I
por: Lal, Preet, et al.
Publicado: (2017)

Correction: Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome
por: Hoffman, Olivia, et al.
Publicado: (2017)

HuR modulation counteracts lipopolysaccharide response in murine macrophages
por: Bonomo, Isabelle, et al.
Publicado: (2023)

Regulation of AT1R expression through HuR by insulin
por: Paukku, Kirsi, et al.
Publicado: (2012)

Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2019)

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process
por: Salminen, Antero, et al.
Publicado: (2012)

Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs
por: Yoon, Je-Hyun, et al.
Publicado: (2014)

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
por: Kaur, Kawaljit, et al.
Publicado: (2017)

Correction: Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2023)

ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis
por: Zhang, Jinjin, et al.
Publicado: (2022)

HuB and HuD repress telomerase activity by dissociating HuR from TERC
por: Cheng, Xiaolei, et al.
Publicado: (2021)

Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis
por: De Santis, Riccardo, et al.
Publicado: (2019)

Regulation of HuR by DNA Damage Response Kinases
por: Kim, Hyeon Ho, et al.
Publicado: (2010)

Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
por: Lachiondo-Ortega, Sofia, et al.
Publicado: (2022)

The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology
por: Hyttinen, Juha M. T., et al.
Publicado: (2019)

HSF1 REGULATION OF β-CATENIN IN MAMMARY CANCER CELLS THROUGH CONTROL OF HUR / ELAVL1 EXPRESSION
por: Chou, Shiuh-Dih, et al.
Publicado: (2014)

Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction
por: Bronicki, Lucas M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_dq0mdncg9s5prjvkb1p89hjigs