Role of Minor Groove Width and Hydration Pattern on Amsacrine Interaction with DNA

Amsacrine is an anilinoacridine derivative anticancer drug, used to treat a wide variety of malignancies. In cells, amsacrine poisons topoisomerase 2 by stabilizing DNA-drug-enzyme ternary complex. Presence of amsacrine increases the steady-state concentration of these ternary complexes which in tur...

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Detalles Bibliográficos
Autores principales: Jangir, Deepak K., Kundu, Suman, Mehrotra, Ranjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726726/
https://www.ncbi.nlm.nih.gov/pubmed/23922861
http://dx.doi.org/10.1371/journal.pone.0069933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726726/
https://www.ncbi.nlm.nih.gov/pubmed/23922861
http://dx.doi.org/10.1371/journal.pone.0069933

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