TNF-α Decreases VEGF Secretion in Highly Polarized RPE Cells but Increases It in Non-Polarized RPE Cells Related to Crosstalk between JNK and NF-κB Pathways

Asymmetrical secretion of vascular endothelial growth factor (VEGF) by retinal pigment epithelial (RPE) cells in situ is critical for maintaining the homeostasis of the retina and choroid. VEGF is also involved in the development and progression of age-related macular degeneration (AMD). We studied...

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Detalles Bibliográficos
Autores principales: Terasaki, Hiroto, Kase, Satoru, Shirasawa, Makoto, Otsuka, Hiroki, Hisatomi, Toshio, Sonoda, Shozo, Ishida, Susumu, Ishibashi, Tatsuro, Sakamoto, Taiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726732/
https://www.ncbi.nlm.nih.gov/pubmed/23922887
http://dx.doi.org/10.1371/journal.pone.0069994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726732/
https://www.ncbi.nlm.nih.gov/pubmed/23922887
http://dx.doi.org/10.1371/journal.pone.0069994

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