tRNA Binding to Antitumor Drug Doxorubicin and Its Analogue

The binding sites of antitumor drug doxorubicin (DOX) and its analogue N-(trifluoroacetyl) doxorubicin (FDOX) with tRNA were located, using FTIR, CD, fluorescence spectroscopic methods and molecular modeling. Different binding sites are involved in drug-tRNA adducts with DOX located in the vicinity...

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Detalles Bibliográficos
Autores principales: Agudelo, Daniel, Bourassa, Philippe, Beauregard, Marc, Bérubé, Gervais, Tajmir-Riahi, Heidar-Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726733/
https://www.ncbi.nlm.nih.gov/pubmed/23922696
http://dx.doi.org/10.1371/journal.pone.0069248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726733/
https://www.ncbi.nlm.nih.gov/pubmed/23922696
http://dx.doi.org/10.1371/journal.pone.0069248

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