An Activating Mutation Reveals a Second Binding Mode of the Integrin α2 I Domain to the GFOGER Motif in Collagens

The GFOGER motif in collagens (O denotes hydroxyproline) represents a high-affinity binding site for all collagen-binding integrins. Other GxOGER motifs require integrin activation for maximal binding. The E318W mutant of the integrin α2β1 I domain displays a relaxed collagen specificity, typical of...

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Detalles Bibliográficos
Autores principales: Carafoli, Federico, Hamaia, Samir W., Bihan, Dominique, Hohenester, Erhard, Farndale, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726769/
https://www.ncbi.nlm.nih.gov/pubmed/23922814
http://dx.doi.org/10.1371/journal.pone.0069833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726769/
https://www.ncbi.nlm.nih.gov/pubmed/23922814
http://dx.doi.org/10.1371/journal.pone.0069833

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