Synthesis, Structure and Antibacterial Activity of Potent DNA Gyrase Inhibitors: N′-Benzoyl-3-(4-Bromophenyl)-1H-Pyrazole-5-Carbohydrazide Derivatives

A total of 19 novel (3a–3s) N′-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide analogs were designed, synthesized, and evaluated for biological activities as potential DNA gyrase inhibitors. The results showed that compound 3k can strongly inhibit Staphylococcus aureus DNA gyrase and Bacillus...

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Detalles Bibliográficos
Autores principales: Sun, Juan, Lv, Peng-Cheng, Yin, Yong, Yuan, Rong-Ju, Ma, Jian, Zhu, Hai-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726784/
https://www.ncbi.nlm.nih.gov/pubmed/23922790
http://dx.doi.org/10.1371/journal.pone.0069751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726784/
https://www.ncbi.nlm.nih.gov/pubmed/23922790
http://dx.doi.org/10.1371/journal.pone.0069751

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