Cargando…
Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations
Ion channels of the DEG/ENaC family can induce neurodegeneration under conditions in which they become hyperactivated. The Caenorhabditis elegans DEG/ENaC channel MEC-4(d) encodes a mutant channel with a substitution in the pore domain that causes swelling and death of the six touch neurons in which...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727304/ https://www.ncbi.nlm.nih.gov/pubmed/23898007 http://dx.doi.org/10.1085/jgp.201310974 |