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Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations

Ion channels of the DEG/ENaC family can induce neurodegeneration under conditions in which they become hyperactivated. The Caenorhabditis elegans DEG/ENaC channel MEC-4(d) encodes a mutant channel with a substitution in the pore domain that causes swelling and death of the six touch neurons in which...

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Detalles Bibliográficos
Autores principales:	Wang, Ying, Matthewman, Cristina, Han, Lu, Miller, Tyne, Miller, David M., Bianchi, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727304/ https://www.ncbi.nlm.nih.gov/pubmed/23898007 http://dx.doi.org/10.1085/jgp.201310974

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