Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels

Voltage-gated sodium channels are critical for the generation and propagation of electrical signals in most excitable cells. Activation of Na(+) channels initiates an action potential, and fast inactivation facilitates repolarization of the membrane by the outward K(+) current. Fast inactivation is...

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Detalles Bibliográficos
Autores principales: Capes, Deborah L., Goldschen-Ohm, Marcel P., Arcisio-Miranda, Manoel, Bezanilla, Francisco, Chanda, Baron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727307/
https://www.ncbi.nlm.nih.gov/pubmed/23858005
http://dx.doi.org/10.1085/jgp.201310998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727307/
https://www.ncbi.nlm.nih.gov/pubmed/23858005
http://dx.doi.org/10.1085/jgp.201310998

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