Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes

Hyperglycemia, like aging, induces chromatin remodeling in mouse hepatocytes in comparison to normoglycemia and younger age, respectively. Changes in glucose metabolism also affect the action and expression of sirtuins, promoting changes in chromatin conformation and dynamics. Here we investigate th...

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Detalles Bibliográficos
Autores principales: Ghiraldini, Flávia Gerelli, Crispim, Ana Carolina Vitolo, Mello, Maria Luiza Silveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727938/
https://www.ncbi.nlm.nih.gov/pubmed/23761075
http://dx.doi.org/10.1091/mbc.E13-04-0186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727938/
https://www.ncbi.nlm.nih.gov/pubmed/23761075
http://dx.doi.org/10.1091/mbc.E13-04-0186

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