Cargando…

Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes

Hyperglycemia, like aging, induces chromatin remodeling in mouse hepatocytes in comparison to normoglycemia and younger age, respectively. Changes in glucose metabolism also affect the action and expression of sirtuins, promoting changes in chromatin conformation and dynamics. Here we investigate th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghiraldini, Flávia Gerelli, Crispim, Ana Carolina Vitolo, Mello, Maria Luiza Silveira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727938/ https://www.ncbi.nlm.nih.gov/pubmed/23761075 http://dx.doi.org/10.1091/mbc.E13-04-0186

Ejemplares similares

Effects of hyperglycemia on the regulation and expression of the Apoe, Igfbp1 and Foxo1 genes and on nuclear phenotypes in HepG2 cells
por: Ghiraldini, Flávia G, et al.
Publicado: (2013)

Changes in Liver Cell DNA Methylation Status in Diabetic Mice Affect Its FT-IR Characteristics
por: Vidal, Benedicto de Campos, et al.
Publicado: (2014)

Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver
por: Ghiraldini, Flávia G, et al.
Publicado: (2014)

Nuclear Sirtuins and the Aging of the Immune System
por: Gámez-García, Andrés, et al.
Publicado: (2021)

Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α
por: Ren, Huihui, et al.
Publicado: (2021)

Sirtuins and DNA damage repair: SIRT7 comes to play
por: Vazquez, Berta N., et al.
Publicado: (2017)

Hepatocyte Sirtuin 6 Protects against Atherosclerosis and Steatohepatitis by Regulating Lipid Homeostasis
por: Zhu, Yingdong, et al.
Publicado: (2023)

Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response
por: Moreli, Jusciele B., et al.
Publicado: (2016)

Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability
por: Wang, Hao-Lian, et al.
Publicado: (2022)

Sirtuins: New Roles for Sirtuins in Aging and Disease
por: Chua, Katrin
Publicado: (2020)

Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
por: Wang, Yating, et al.
Publicado: (2022)

COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis
por: Barreto, Ester A., et al.
Publicado: (2023)

Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena
por: Slade, Kristin M, et al.
Publicado: (2011)

Investigation on the Protective Effect of α-Mannan against the DNA Damage Induced by Aflatoxin B(1) in Mouse Hepatocytes
por: Madrigal-Santillán, Eduardo, et al.
Publicado: (2009)

Sirtuins in metabolism, DNA repair and cancer
por: Mei, Zhen, et al.
Publicado: (2016)

Nuclear Integrity but Not Topology of Mouse Sperm Chromosome is Affected by Oxidative DNA Damage
por: Champroux, Alexandre, et al.
Publicado: (2018)

Intraoperative Hyperglycemia during Liver Resection: Predictors and Association with the Extent of Hepatocytes Injury
por: Han, Sangbin, et al.
Publicado: (2014)

Apc and p53 interaction in DNA damage and genomic instability in hepatocytes
por: Méniel, Valérie, et al.
Publicado: (2014)

Dysplastic Hepatocytes Develop Nuclear Inclusions in a Mouse Model of Viral Hepatitis
por: Thakur, Priyanka, et al.
Publicado: (2014)

Sirtuins, aging and diseases
por: Guarente, Leonard
Publicado: (2012)

Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells
por: Yoon, Kyoung B., et al.
Publicado: (2016)

Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress
por: Simoneau, Antoine, et al.
Publicado: (2016)

Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes
por: Wolters, Jarno E. J., et al.
Publicado: (2017)

Fluoride Exposure Suppresses Proliferation and Enhances Endoplasmic Reticulum Stress and Apoptosis Pathways in Hepatocytes by Downregulating Sirtuin-1
por: Yu, Yanlong, et al.
Publicado: (2022)

Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes
por: Locatelli, Monica, et al.
Publicado: (2020)

Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing
por: Ma, Xiao-Ru, et al.
Publicado: (2022)

Sirtuins as regulators of mammalian aging
por: Naiman, Shoshana, et al.
Publicado: (2012)

IRS-1 gene polymorphism and DNA damage in pregnant women with diabetes or mild gestational hyperglycemia
por: Gelaleti, Rafael B, et al.
Publicado: (2015)

Glycyrrhizin mitigates inflammatory bone loss and promotes expression of senescence-protective sirtuins in an aging mouse model of periprosthetic osteolysis
por: Yamada, Chiaki, et al.
Publicado: (2021)

Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage
por: Burger, Kaspar, et al.
Publicado: (2018)

Sirtuins at the Breaking Point: SIRT6 in DNA Repair
por: Lombard, David B.
Publicado: (2009)

Genotoxicity of a Variety of Hydrazine Derivatives in the Hepatocyte Primary Culture/DNA Repair Test Using Rat and Mouse Hepatocytes
por: Mori, Hideki, et al.
Publicado: (1988)

The nuclear matrix protein HNRNPU maintains 3D genome architecture globally in mouse hepatocytes
por: Fan, Hui, et al.
Publicado: (2018)

Severity of Hepatocyte Damage and Prognosis in Cirrhotic Patients Correlate with Hepatocyte Magnesium Depletion
por: Parisse, Simona, et al.
Publicado: (2023)

Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma
por: Kumar, Deepak, et al.
Publicado: (2022)

Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors
por: Schmid, Nina, et al.
Publicado: (2021)

Azelnidipine protects myocardium in hyperglycemia-induced cardiac damage
por: Kain, Vasundhara, et al.
Publicado: (2010)

Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho
por: Borsky, Pavel, et al.
Publicado: (2023)

DNA damage induces nuclear translocation of parkin
por: Kao, Shyan-Yuan
Publicado: (2009)

Regulation of Nuclear Mechanics and the Impact on DNA Damage
por: dos Santos, Ália, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9je84e7n47pjjimc76du03cf9v