CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2, triggering repression of global protein synthesis coincident with preferential translation of ATF4, a transcriptional activator of the integrated stress response (ISR). Depending on the extent of protein disrupti...

Descripción completa

Detalles Bibliográficos
Autores principales: Teske, Brian F., Fusakio, Michael E., Zhou, Donghui, Shan, Jixiu, McClintick, Jeanette N., Kilberg, Michael S., Wek, Ronald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727939/
https://www.ncbi.nlm.nih.gov/pubmed/23761072
http://dx.doi.org/10.1091/mbc.E13-01-0067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727939/
https://www.ncbi.nlm.nih.gov/pubmed/23761072
http://dx.doi.org/10.1091/mbc.E13-01-0067

Ejemplares similares