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Selective constraint, background selection, and mutation accumulation variability within and between human populations
BACKGROUND: Regions of the genome that are under evolutionary constraint across multiple species have previously been used to identify functional sequences in the human genome. Furthermore, it is known that there is an inverse relationship between evolutionary constraint and the allele frequency of...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727949/ https://www.ncbi.nlm.nih.gov/pubmed/23875710 http://dx.doi.org/10.1186/1471-2164-14-495 |