Recombinant Prion Protein Refolded with Lipid and RNA Has the Biochemical Hallmarks of a Prion but Lacks In Vivo Infectivity

During prion infection, the normal, protease-sensitive conformation of prion protein (PrP(C)) is converted via seeded polymerization to an abnormal, infectious conformation with greatly increased protease-resistance (PrP(Sc)). In vitro, protein misfolding cyclic amplification (PMCA) uses PrP(Sc) in...

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Detalles Bibliográficos
Autores principales: Timmes, Andrew G., Moore, Roger A., Fischer, Elizabeth R., Priola, Suzette A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728029/
https://www.ncbi.nlm.nih.gov/pubmed/23936256
http://dx.doi.org/10.1371/journal.pone.0071081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728029/
https://www.ncbi.nlm.nih.gov/pubmed/23936256
http://dx.doi.org/10.1371/journal.pone.0071081

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