NVP-LDE225, a Potent and Selective SMOOTHENED Antagonist Reduces Melanoma Growth In Vitro and In Vivo

Melanoma is one of the most aggressive cancers and its incidence is increasing worldwide. So far there are no curable therapies especially after metastasis. Due to frequent mutations in members of the mitogen-activated protein kinase (MAPK) signaling pathway, this pathway is constitutively active in...

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Detalles Bibliográficos
Autores principales: Jalili, Ahmad, Mertz, Kirsten D., Romanov, Julia, Wagner, Christine, Kalthoff, Frank, Stuetz, Anton, Pathria, Gaurav, Gschaider, Melanie, Stingl, Georg, Wagner, Stephan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728309/
https://www.ncbi.nlm.nih.gov/pubmed/23935925
http://dx.doi.org/10.1371/journal.pone.0069064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728309/
https://www.ncbi.nlm.nih.gov/pubmed/23935925
http://dx.doi.org/10.1371/journal.pone.0069064

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