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Assumptions and Properties of Limiting Pathway Models for Analysis of Epistasis in Complex Traits

For most complex traits, results from genome-wide association studies show that the proportion of the phenotypic variance attributable to the additive effects of individual SNPs, that is, the heritability explained by the SNPs, is substantially less than the estimate of heritability obtained by stan...

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Detalles Bibliográficos
Autores principales: Stringer, Sven, Derks, Eske M., Kahn, René S., Hill, William G., Wray, Naomi R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728313/
https://www.ncbi.nlm.nih.gov/pubmed/23935903
http://dx.doi.org/10.1371/journal.pone.0068913