Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

OBJECTIVE: To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic utility in facilitating renal recovery...

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Detalles Bibliográficos
Autores principales: Howell, Gina M., Gomez, Hernando, Collage, Richard D., Loughran, Patricia, Zhang, Xianghong, Escobar, Daniel A., Billiar, Timothy R., Zuckerbraun, Brian S., Rosengart, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728340/
https://www.ncbi.nlm.nih.gov/pubmed/23936035
http://dx.doi.org/10.1371/journal.pone.0069520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728340/
https://www.ncbi.nlm.nih.gov/pubmed/23936035
http://dx.doi.org/10.1371/journal.pone.0069520

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