Cargando…

Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

OBJECTIVE: To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic utility in facilitating renal recovery...

Descripción completa

Detalles Bibliográficos
Autores principales:	Howell, Gina M., Gomez, Hernando, Collage, Richard D., Loughran, Patricia, Zhang, Xianghong, Escobar, Daniel A., Billiar, Timothy R., Zuckerbraun, Brian S., Rosengart, Matthew R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728340/ https://www.ncbi.nlm.nih.gov/pubmed/23936035 http://dx.doi.org/10.1371/journal.pone.0069520

Ejemplares similares

Reducing Animal Use with a Biotelemetry-Enhanced Murine Model of Sepsis
por: Lewis, Anthony, et al.
Publicado: (2017)

Inhaled Carbon Monoxide Protects against the Development of Shock and Mitochondrial Injury following Hemorrhage and Resuscitation
por: Gomez, Hernando, et al.
Publicado: (2015)

Lipopolysaccharide Stimulates p62-Dependent Autophagy-Like Aggregate Clearance in Hepatocytes
por: Chen, Christine, et al.
Publicado: (2014)

Role of nitric oxide in inflammation and tissue injury during endotoxemia and hemorrhagic shock.
por: Shah, N S, et al.
Publicado: (1998)

Heme Oxygenase-2 Localizes to Mitochondria and Regulates Hypoxic Responses in Hepatocytes
por: Waltz, Paul K., et al.
Publicado: (2018)

Dipyridamole augments the antiinflammatory response during human endotoxemia
por: Ramakers, Bart P, et al.
Publicado: (2011)

AMP-protein kinase may protect against sepsis-induced acute kidney injury through modulation of immune response and endothelial activation
por: Gomez, H, et al.
Publicado: (2014)

HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling
por: Tsung, Allan, et al.
Publicado: (2007)

Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis
por: Yang, Chenxuan, et al.
Publicado: (2019)

Carbon monoxide therapy protects against hepatic microvascular injury in a mouse model of murine hemorrhagic shock and resuscitation
por: Gomez, H, et al.
Publicado: (2012)

Emodin reactivated autophagy and alleviated inflammatory lung injury in mice with lethal endotoxemia
por: Dong, Yan, et al.
Publicado: (2019)

Endotoxin Engages Mitochondrial Quality Control via an iNOS-Reactive Oxygen Species Signaling Pathway in Hepatocytes
por: Cyr, Anthony, et al.
Publicado: (2019)

Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function
por: Porta, Francesca, et al.
Publicado: (2006)

Hyperinflammation, T cells, and endotoxemia
por: Inoue, Makoto, et al.
Publicado: (2015)

Amino Acids, Independent of Insulin, Attenuate Skeletal Muscle Autophagy in Neonatal Pigs during Endotoxemia
por: Hernandez-García, Adriana, et al.
Publicado: (2016)

Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis
por: Li, Qirui, et al.
Publicado: (2018)

Mode of renal replacement therapy determines endotoxemia and neutrophil dysfunction in chronic kidney disease
por: Lemesch, Sandra, et al.
Publicado: (2016)

Carbon monoxide reverses established pulmonary hypertension
por: Zuckerbraun, Brian S., et al.
Publicado: (2006)

Endotoxemia is associated with acute coronary syndrome in patients with end stage kidney disease
por: Hsu, Chien-Chin, et al.
Publicado: (2017)

Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway
por: Tang, Da, et al.
Publicado: (2021)

Carbon Monoxide Protects against Liver Failure through Nitric Oxide–induced Heme Oxygenase 1
por: Zuckerbraun, Brian S., et al.
Publicado: (2003)

Blunt cerebrovascular injury in elderly fall patients: are we screening enough?
por: Anto, Vincent P., et al.
Publicado: (2018)

Deficiency of IRG1/ itaconate aggravates endotoxemia-induced acute lung injury by inhibiting autophagy in mice
por: Qiu, Jing-Huan, et al.
Publicado: (2022)

Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA
por: Dyer, Mitchell R., et al.
Publicado: (2018)

Protective Effects of Bee Venom against Endotoxemia-Related Acute Kidney Injury in Mice
por: Kim, Jung-Yeon, et al.
Publicado: (2020)

Endotoxemia analysis in the postoperative period following cardiac surgery
por: Campos Gómez, A, et al.
Publicado: (2015)

Autophagy in kidney transplants of sirolimus treated recipients
por: Bhayana, Sagar, et al.
Publicado: (2017)

Effect of Rifaximin Treatment on Endotoxemia and Insulin Sensitivity in Humans
por: Finlin, Brian S, et al.
Publicado: (2019)

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients
por: Abdul-Malak, Othman, et al.
Publicado: (2016)

Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding
por: Lin, Minjie, et al.
Publicado: (2020)

Effects of tigecycline and doxycycline in porcine endotoxemia
por: Von Seth, M, et al.
Publicado: (2011)

Endotoxemia is associated with an adverse metabolic profile
por: Määttä, Anne-Mari, et al.
Publicado: (2020)

The Importance of Food for Endotoxemia and an Inflammatory Response
por: Erlanson-Albertsson, Charlotte, et al.
Publicado: (2021)

Lung protective effect of Ticagrelor in endotoxemia
por: Mueen, Ruaa Murtada, et al.
Publicado: (2023)

Reduced cleavage of von willebrand factor by ADAMTS13 is associated with microangiopathic acute kidney injury following trauma
por: Plautz, William E., et al.
Publicado: (2022)

Nanoparticles augment the therapeutic window of RT and immunotherapy for treating cancers: pivotal role of autophagy
por: Wu, Yuan-Hua, et al.
Publicado: (2023)

Toxins, Toxicity, and Endotoxemia: A Historical and Clinical Perspective for Chiropractors
por: Seaman, David R.
Publicado: (2016)

Evidence for metabolic endotoxemia in obese and diabetic Gambian women
por: Hawkesworth, S, et al.
Publicado: (2013)

A Proteomics-Based Assessment of Inflammation Signatures in Endotoxemia
por: Burnap, Sean A., et al.
Publicado: (2021)

Abrogation of Plasminogen Activator Inhibitor-1-Vitronectin Interaction Ameliorates Acute Kidney Injury in Murine Endotoxemia
por: Gupta, Kamlesh K., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_dpr790s90g8oge3qta0r9dftic