A Novel Tumor Suppressor Function of Glycine N-Methyltransferase Is Independent of Its Catalytic Activity but Requires Nuclear Localization

Glycine N-methyltransferase (GNMT), an abundant cytosolic enzyme, catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine generating S-adenosylhomocysteine and sarcosine (N-methylglycine). This reaction is regulated by 5-methyltetrahydrofolate, which inhibits the enzyme c...

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Detalles Bibliográficos
Autores principales: DebRoy, Suchandra, Kramarenko, Inga I., Ghose, Sampa, Oleinik, Natalia V., Krupenko, Sergey A., Krupenko, Natalia I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728347/
https://www.ncbi.nlm.nih.gov/pubmed/23936142
http://dx.doi.org/10.1371/journal.pone.0070062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728347/
https://www.ncbi.nlm.nih.gov/pubmed/23936142
http://dx.doi.org/10.1371/journal.pone.0070062

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