Cargando…

Structure-Based Mechanism for Early PLP-Mediated Steps of Rabbit Cytosolic Serine Hydroxymethyltransferase Reaction

Serine hydroxymethyltransferase catalyzes the reversible interconversion of L-serine and glycine with transfer of one-carbon groups to and from tetrahydrofolate. Active site residue Thr254 is known to be involved in the transaldimination reaction, a crucial step in the catalytic mechanism of all pyr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Salvo, Martino L., Scarsdale, J. Neel, Kazanina, Galina, Contestabile, Roberto, Schirch, Verne, Wright, H. Tonie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728543/ https://www.ncbi.nlm.nih.gov/pubmed/23956983 http://dx.doi.org/10.1155/2013/458571

Ejemplares similares

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism
por: Guiducci, Giulia, et al.
Publicado: (2019)

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells
por: Marani, Marina, et al.
Publicado: (2015)

Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models
por: Ruszkowski, Milosz, et al.
Publicado: (2019)

Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity
por: Bouzidi, Amani, et al.
Publicado: (2020)

Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
por: Nonaka, Hiroshi, et al.
Publicado: (2019)

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization
por: Pornthanakasem, Wichai, et al.
Publicado: (2012)

PLP-Dependent Enzymes
por: Paiardini, Alessandro, et al.
Publicado: (2014)

Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori
por: Sodolescu, Andreea, et al.
Publicado: (2018)

Determinants of Thermostability in Serine Hydroxymethyltransferase Identified by Principal Component Analysis
por: Leng, Fei, et al.
Publicado: (2017)

Induction of serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastoma
por: Clark, Rachael A., et al.
Publicado: (2022)

Editorial: PLP-Dependent Enzymes: Extraordinary Versatile Catalysts and Ideal Biotechnological Tools for the Production of Unnatural Amino Acids and Related Compounds
por: Di Salvo, Martino L., et al.
Publicado: (2020)

Insights Into the Known (13)C Depletion of Methane—Contribution of the Kinetic Isotope Effects on the Serine Hydroxymethyltransferase Reaction
por: Gleixner, Gerd
Publicado: (2022)

Chloroplastic Serine Hydroxymethyltransferase From Medicago truncatula: A Structural Characterization
por: Ruszkowski, Milosz, et al.
Publicado: (2018)

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis
por: Zeng, Yuanyuan, et al.
Publicado: (2021)

Characterization of thermostable serine hydroxymethyltransferase for β-hydroxy amino acids synthesis
por: Ma’ruf, Ilma Fauziah, et al.
Publicado: (2022)

Serine hydroxymethyltransferase controls blood-meal digestion in the midgut of Aedes aegypti mosquitoes
por: Li, Xuemei, et al.
Publicado: (2019)

Exploring the Cold-Adaptation Mechanism of Serine Hydroxymethyltransferase by Comparative Molecular Dynamics Simulations
por: Zhang, Zhi-Bi, et al.
Publicado: (2021)

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy
por: Pikman, Yana, et al.
Publicado: (2021)

Serine Hydroxymethyltransferase 1 Is Essential for Primary-Root Growth at Low-Sucrose Conditions
por: Yuan, Yang, et al.
Publicado: (2022)

Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade
por: Yin, Ke
Publicado: (2015)

Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control
por: Chitnumsub, Penchit, et al.
Publicado: (2014)

Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma
por: Woo, Chern Chiuh, et al.
Publicado: (2016)

High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients
por: Shi, Haihong, et al.
Publicado: (2019)

Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate
por: Ota, Tomoki, et al.
Publicado: (2021)

Characterization of serine hydroxymethyltransferase GlyA as a potential source of D-alanine in Chlamydia pneumoniae
por: De Benedetti, Stefania, et al.
Publicado: (2014)

Soybean Cyst Nematode Resistance Emerged via Artificial Selection of Duplicated Serine Hydroxymethyltransferase Genes
por: Wu, Xiao-Yi, et al.
Publicado: (2016)

Use of molecular beacons to verify that the serine hydroxymethyltransferase pseudogene SHMT-ps1 is unique to the order Primates
por: Devor, Eric J
Publicado: (2001)

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities
por: Chitnumsub, Penchit, et al.
Publicado: (2014)

A novel serine hydroxymethyltransferase from Arthrobacter nicotianae: characterization and improving catalytic efficiency by rational design
por: Jiang, Wei, et al.
Publicado: (2014)

Genome-wide identification and expression analysis of serine hydroxymethyltransferase (SHMT) gene family in tomato (Solanum lycopersicum)
por: Liu, Zesheng, et al.
Publicado: (2022)

Serine hydroxymethyltransferase 2 predicts unfavorable outcomes in multiple cancer: a systematic review and meta-analysis
por: Du, Juan, et al.
Publicado: (2022)

In Silico and In Vitro Potential of FDA-Approved Drugs for Antimalarial Drug Repurposing against Plasmodium Serine Hydroxymethyltransferases
por: Mee-udorn, Pitchayathida, et al.
Publicado: (2023)

Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography
por: Drago, Victoria N., et al.
Publicado: (2023)

Serine Hydroxymethyltransferase ShrA (PA2444) Controls Rugose Small-Colony Variant Formation in Pseudomonas aeruginosa
por: Pu, Mingming, et al.
Publicado: (2018)

Heterologous Expression of Serine Hydroxymethyltransferase-3 From Rice Confers Tolerance to Salinity Stress in E. coli and Arabidopsis
por: Mishra, Pragya, et al.
Publicado: (2019)

Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors
por: Makino, Yuko, et al.
Publicado: (2022)

Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition
por: Gandhi, Amit K., et al.
Publicado: (2012)

Pyridoxal 5′-Phosphate Is a Slow Tight Binding Inhibitor of E. coli Pyridoxal Kinase
por: Ghatge, Mohini S., et al.
Publicado: (2012)

Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum
por: Read, Martin, et al.
Publicado: (2010)

Functional Identification of Serine Hydroxymethyltransferase as a Key Gene Involved in Lysostaphin Resistance and Virulence Potential of Staphylococcus aureus Strains
por: Batool, Nayab, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_uqdt5uslme7mufgs65gmk00i6j