Crystal Structure of Pim1 Kinase in Complex with a Pyrido[4,3-D]Pyrimidine Derivative Suggests a Unique Binding Mode

Human Pim1 kinase is a serine/threonine protein kinase that plays important biological roles in cell survival, apoptosis, proliferation, and differentiation. Moreover, Pim1 is up-regulated in various hematopoietic malignancies and solid tumors. Thus, Pim1 is an attractive target for cancer therapeut...

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Detalles Bibliográficos
Autores principales: Lee, Sang Jae, Han, Byeong-Gu, Cho, Jea-Won, Choi, Jang-Sik, Lee, Jaekyoo, Song, Ho-Juhn, Koh, Jong Sung, Lee, Byung Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729456/
https://www.ncbi.nlm.nih.gov/pubmed/23936194
http://dx.doi.org/10.1371/journal.pone.0070358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729456/
https://www.ncbi.nlm.nih.gov/pubmed/23936194
http://dx.doi.org/10.1371/journal.pone.0070358

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