Cargando…

Crucial Residue Involved in L-Lactate Recognition by Human Monocarboxylate Transporter 4 (hMCT4)

BACKGROUND: Monocarboxylate transporters (MCTs) transport monocarboxylates such as lactate, pyruvate and ketone bodies. These transporters are very attractive therapeutic targets in cancer. Elucidations of the functions and structures of MCTs is necessary for the development of effective medicine wh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sasaki, Shotaro, Kobayashi, Masaki, Futagi, Yuya, Ogura, Jiro, Yamaguchi, Hiroaki, Takahashi, Natsuko, Iseki, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729688/ https://www.ncbi.nlm.nih.gov/pubmed/23935841 http://dx.doi.org/10.1371/journal.pone.0067690

Ejemplares similares

Involvement of Histidine Residue His382 in pH Regulation of MCT4 Activity
por: Sasaki, Shotaro, et al.
Publicado: (2015)

Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor Microenvironment
por: Liu, Tian, et al.
Publicado: (2023)

A Holistic Evolutionary and 3D Pharmacophore Modelling Study Provides Insights into the Metabolism, Function, and Substrate Selectivity of the Human Monocarboxylate Transporter 4 (hMCT4)
por: Papakonstantinou, Eleni, et al.
Publicado: (2021)

Monocarboxylate Transporter 4 (MCT4) Overexpression Is Correlated with Poor Prognosis of Osteosarcoma
por: Liu, Yannan, et al.
Publicado: (2019)

Inhibition of monocarboxylate transporters (MCT) 1 and 4 reduces exercise capacity in mice
por: Kitaoka, Yu, et al.
Publicado: (2022)

Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10
por: Porst, Theresa, et al.
Publicado: (2021)

High expression of monocarboxylate transporter 4 (MCT 4), but not MCT 1, predicts poor prognosis in patients with non-small cell lung cancer
por: Tong, Ying-Hui, et al.
Publicado: (2021)

Monocarboxylate Transporters 1–4 in NSCLC: MCT1 Is an Independent Prognostic Marker for Survival
por: Eilertsen, Marte, et al.
Publicado: (2014)

Monocarboxylate Transporter 1 (MCT1) in Liver Pathology
por: Droździk, Marek, et al.
Publicado: (2020)

Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer
por: Pértega-Gomes, Nelma, et al.
Publicado: (2011)

Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer
por: Bisetto, Sara, et al.
Publicado: (2018)

Autoregulation of H(+)/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production
por: Blaszczak, Wiktoria, et al.
Publicado: (2022)

Monocarboxylate Transporter 1 (MCT1) Mediates Succinate Export in the Retina
por: Bisbach, Celia M., et al.
Publicado: (2022)

Impact of the Monocarboxylate Transporter-1 (MCT1)-Mediated Cellular Import of Lactate on Stemness Properties of Human Pancreatic Adenocarcinoma Cells †
por: Sandforth, Leontine, et al.
Publicado: (2020)

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer
por: Latif, Ayşe, et al.
Publicado: (2017)

MCT1 in Invasive Ductal Carcinoma: Monocarboxylate Metabolism and Aggressive Breast Cancer
por: Johnson, Jennifer M., et al.
Publicado: (2017)

Role and Clinical Significance of Monocarboxylate Transporter 8 (MCT8) During Pregnancy
por: Thomas, Jinsu, et al.
Publicado: (2023)

Comprehensive Analysis of Monocarboxylate Transporter 4 (MCT4) expression in breast cancer prognosis and immune infiltration via integrated bioinformatics analysis
por: Yuan, Chen, et al.
Publicado: (2021)

Regulation of Acetate Utilization by Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC)
por: Jeon, Jeong Yong, et al.
Publicado: (2018)

The Hepatic Monocarboxylate Transporter 1 (MCT1) Contributes to the Regulation of Food Anticipation in Mice
por: Martini, Tomaz, et al.
Publicado: (2021)

Tissue expression of lactate transporters (MCT1 and MCT4) and prognosis of malignant pleural mesothelioma (brief report)
por: Dell’Anno, Irene, et al.
Publicado: (2020)

Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4)
por: Ziegler, Kerstin, et al.
Publicado: (2016)

Critical Velocity, Maximal Lactate Steady State, and Muscle MCT1 and MCT4 after Exhaustive Running in Mice
por: Orsi, Juan B., et al.
Publicado: (2023)

Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination
por: Lee, Jae Young, et al.
Publicado: (2017)

Lactate Transporter Monocarboxylate Transporter 4 Induces Bone Pain in Head and Neck Squamous Cell Carcinoma
por: Hasegawa, Kazuaki, et al.
Publicado: (2018)

Monocarboxylate transporter 4 involves in energy metabolism and drug sensitivity in hypoxia
por: Yamaguchi, Atsushi, et al.
Publicado: (2023)

MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism
por: Petersen, Charlotte, et al.
Publicado: (2017)

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells
por: Benjamin, Don, et al.
Publicado: (2018)

New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity
por: Bisetto, Sara, et al.
Publicado: (2019)

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
por: Ovens, Matthew J., et al.
Publicado: (2010)

The Neuroplastin Adhesion Molecules Are Accessory Proteins That Chaperone the Monocarboxylate Transporter MCT2 to the Neuronal Cell Surface
por: Wilson, Marieangela C., et al.
Publicado: (2013)

Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome
por: Leu, Martin, et al.
Publicado: (2021)

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10
por: Ovens, Matthew J., et al.
Publicado: (2010)

The genetic variation in Monocarboxylic acid transporter 2 (MCT2) has functional and clinical relevance with male infertility
por: Lee, Jinu, et al.
Publicado: (2014)

Evaluation of Monocarboxylate Transporter 4 (MCT4) Expression and Its Prognostic Significance in Circulating Tumor Cells From Patients With Early Stage Non-Small-Cell Lung Cancer
por: Markou, Athina, et al.
Publicado: (2021)

Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma
por: Long, Yaping, et al.
Publicado: (2018)

Inhibition of Hypothalamic MCT4 and MCT1–MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions
por: Elizondo-Vega, Roberto, et al.
Publicado: (2019)

Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter
por: Higuchi, Kei, et al.
Publicado: (2022)

MCT4 regulates de novo pyrimidine biosynthesis in GBM in a lactate-independent manner
por: Spina, Raffaella, et al.
Publicado: (2020)

Monocarboxylate Transporters and Lactate Metabolism in Equine Athletes: A Review
por: Pösö, AR
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_j8jn3u4b1rabksmhr3umbivu9m