Molecular Dynamics Simulations of Sonic Hedgehog-Receptor and Inhibitor Complexes and Their Applications for Potential Anticancer Agent Discovery

The sonic hedgehog (Shh) signaling pathway is necessary for a variety of development and differentiation during embryogenesis as well as maintenance and renascence of diverse adult tissues. However, an abnormal activation of the signaling pathway is related to various cancers. In this pathway, the S...

Descripción completa

Detalles Bibliográficos
Autores principales: Hwang, Swan, Thangapandian, Sundarapandian, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729836/
https://www.ncbi.nlm.nih.gov/pubmed/23935859
http://dx.doi.org/10.1371/journal.pone.0068271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729836/
https://www.ncbi.nlm.nih.gov/pubmed/23935859
http://dx.doi.org/10.1371/journal.pone.0068271

Ejemplares similares