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Conserved Roles of the Prion Protein Domains on Subcellular Localization and Cell-Cell Adhesion
Analyses of cultured cells and transgenic mice expressing prion protein (PrP) deletion mutants have revealed that some properties of PrP -such as its ability to misfold, aggregate and trigger neurotoxicity- are controlled by discrete molecular determinants within its protein domains. Although the co...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729945/ https://www.ncbi.nlm.nih.gov/pubmed/23936187 http://dx.doi.org/10.1371/journal.pone.0070327 |