Top-down MS for rapid methionine oxidation site assignment in filgrastim

Protein therapeutics have emerged as a major new class of pharmaceuticals. One important shelf-life-limiting factor of biopharmaceuticals is methionine oxidation, and therefore, it is important that analytical methods are able to thoroughly characterize all possible oxidized variants. Here, we prese...

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Detalles Bibliográficos
Autores principales: Holzmann, Johann, Hausberger, Anna, Rupprechter, Alfred, Toll, Hansjoerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730093/
https://www.ncbi.nlm.nih.gov/pubmed/23831755
http://dx.doi.org/10.1007/s00216-013-7138-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730093/
https://www.ncbi.nlm.nih.gov/pubmed/23831755
http://dx.doi.org/10.1007/s00216-013-7138-0

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