Mouse Genetic Models Reveal Surprising Functions of IκB Kinase Alpha in Skin Development and Skin Carcinogenesis

Gene knockout studies unexpectedly reveal a pivotal role for IκB kinase alpha (IKKα) in mouse embryonic skin development. Skin carcinogenesis experiments show that Ikkα heterozygous mice are highly susceptible to chemical carcinogen or ultraviolet B light (UVB) induced benign and malignant skin tumo...

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Detalles Bibliográficos
Autores principales: Xia, Xiaojun, Park, Eunmi, Fischer, Susan M., Hu, Yinling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730312/
https://www.ncbi.nlm.nih.gov/pubmed/24216703
http://dx.doi.org/10.3390/cancers5010170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730312/
https://www.ncbi.nlm.nih.gov/pubmed/24216703
http://dx.doi.org/10.3390/cancers5010170

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