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Mouse Genetic Models Reveal Surprising Functions of IκB Kinase Alpha in Skin Development and Skin Carcinogenesis

Gene knockout studies unexpectedly reveal a pivotal role for IκB kinase alpha (IKKα) in mouse embryonic skin development. Skin carcinogenesis experiments show that Ikkα heterozygous mice are highly susceptible to chemical carcinogen or ultraviolet B light (UVB) induced benign and malignant skin tumo...

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Detalles Bibliográficos
Autores principales:	Xia, Xiaojun, Park, Eunmi, Fischer, Susan M., Hu, Yinling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730312/ https://www.ncbi.nlm.nih.gov/pubmed/24216703 http://dx.doi.org/10.3390/cancers5010170

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