Cargando…

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

Integrins are transmembrane heterodimeric proteins sensing the cell microenvironment and modulating numerous signalling pathways. Changes in integrin expression between normal and tumoral cells support involvement of specific integrins in tumor progression and aggressiveness. This review highlights...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schaffner, Florence, Ray, Anne Marie, Dontenwill, Monique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730317/ https://www.ncbi.nlm.nih.gov/pubmed/24216697 http://dx.doi.org/10.3390/cancers5010027

Ejemplares similares

β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer
por: Blandin, Anne-Florence, et al.
Publicado: (2015)

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor
por: Nagae, Masamichi, et al.
Publicado: (2012)

RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma
por: Fechter, Pierre, et al.
Publicado: (2019)

Expression of fibronectin, fibronectin isoforms and integrin receptors in melanocytic lesions.
por: Natali, P. G., et al.
Publicado: (1995)

αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
por: Bharadwaj, Mitasha, et al.
Publicado: (2017)

Tumor Angiogenesis in the Absence of Fibronectin or Its Cognate Integrin Receptors
por: Murphy, Patrick A., et al.
Publicado: (2015)

Distinct Binding Interactions of α(5)β(1)-Integrin and Proteoglycans with Fibronectin
por: Kennelly, Thomas M., et al.
Publicado: (2019)

Structural insights into integrin α(5)β(1) opening by fibronectin ligand
por: Schumacher, Stephanie, et al.
Publicado: (2021)

Platelets drive fibronectin fibrillogenesis using integrin αIIbβ3
por: Lickert, Sebastian, et al.
Publicado: (2022)

Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin
por: Sani, Saidu, et al.
Publicado: (2022)

α5β1 Integrin-Fibronectin Interactions Specify Liquid to Solid Phase Transition of 3D Cellular Aggregates
por: Caicedo-Carvajal, Carlos E., et al.
Publicado: (2010)

Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells
por: Renner, Guillaume, et al.
Publicado: (2016)

Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer
por: Cruz da Silva, Elisabete, et al.
Publicado: (2019)

Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma
por: Shi, Kai, et al.
Publicado: (2019)

Integrin Dynamics and Matrix Assembly: Tensin-Dependent Translocation of α(5)β(1) Integrins Promotes Early Fibronectin Fibrillogenesis
por: Pankov, Roumen, et al.
Publicado: (2000)

Integrins and p53 pathways in glioblastoma resistance to temozolomide
por: Martin, Sophie, et al.
Publicado: (2012)

Latent effects of fibronectin, α5β1 integrin, αVβ5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion
por: Lowrie, A G, et al.
Publicado: (2004)

The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA–GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
por: Danen, Erik H.J., et al.
Publicado: (2002)

The interactions between integrin α(5)β(1) of liver cancer cells and fibronectin of fibroblasts promote tumor growth and angiogenesis
por: Peng, Zheng, et al.
Publicado: (2022)

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links
por: González-Tarragó, Víctor, et al.
Publicado: (2017)

Three-dimensional EM structure of the ectodomain of integrin αVβ3 in a complex with fibronectin
por: Adair, Brian D., et al.
Publicado: (2005)

α5β1 Integrin-Mediated Adhesion to Fibronectin Is Required for Axis Elongation and Somitogenesis in Mice
por: Girós, Amparo, et al.
Publicado: (2011)

Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change
por: Su, Yang, et al.
Publicado: (2022)

CD93 promotes β(1) integrin activation and fibronectin fibrillogenesis during tumor angiogenesis
por: Lugano, Roberta, et al.
Publicado: (2018)

Substrate engagement of integrins α(5)β(1) and α(v)β(3) is necessary, but not sufficient, for high directional persistence in migration on fibronectin
por: Missirlis, Dimitris, et al.
Publicado: (2016)

Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
por: Bazigou, Eleni, et al.
Publicado: (2009)

Interaction between Fibronectin and β1 Integrin Is Essential for Tooth Development
por: Saito, Kan, et al.
Publicado: (2015)

The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin
Publicado: (1993)

Participation of Integrin α5β1 in the Fibronectin-Mediated Adherence of Enteroaggregative Escherichia coli to Intestinal Cells
por: Izquierdo, Mariana, et al.
Publicado: (2014)

Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin
por: Van Agthoven, Johannes F., et al.
Publicado: (2014)

Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice
por: Almonte-Becerril, Maylin, et al.
Publicado: (2018)

Pertinent Questions
Publicado: (1888)

Fibronectin is a good catch for integrin
por: Short, Ben
Publicado: (2009)

Fibronectin‐Mediated Inflammatory Signaling Through Integrin α5 in Vascular Remodeling
por: Budatha, Madhusudhan, et al.
Publicado: (2021)

Cancer-associated fibroblasts lead tumor invasion through integrin-β3–dependent fibronectin assembly
por: Attieh, Youmna, et al.
Publicado: (2017)

Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α–induced endothelial hyperpermeability by modulating β1 integrin activation
por: Lee, Ting-Hein, et al.
Publicado: (2019)

Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
por: Agrez, M. V., et al.
Publicado: (1996)

Fibronectin Regulation of Integrin B1 and SLUG in Circulating Tumor Cells
por: Huaman, Jeannette, et al.
Publicado: (2019)

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
por: Mana, Giulia, et al.
Publicado: (2016)

CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling
por: Faurobert, Eva, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_9isdv7rl79be2bi72f6fhfu7tf