ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network

HeLa cells treated with celastrol, a natural compound with inhibitive effect on proteasome, exhibited increase in apoptotic rate and characteristics of apoptosis. To clarify the signal network activated by celastrol to induce apoptosis, both the direct target proteins and undirect target proteins of...

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Detalles Bibliográficos
Autores principales: Feng, L, Zhang, D, Fan, C, Ma, C, Yang, W, Meng, Y, Wu, W, Guan, S, Jiang, B, Yang, M, Liu, X, Guo, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730400/
https://www.ncbi.nlm.nih.gov/pubmed/23846217
http://dx.doi.org/10.1038/cddis.2013.222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730400/
https://www.ncbi.nlm.nih.gov/pubmed/23846217
http://dx.doi.org/10.1038/cddis.2013.222

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