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Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia

Microglia are the resident immune cells in the central nervous system and key players against pathogens and injury. However, persistent microglial activation often exacerbates pathological damage and has been implicated in many neurological diseases. Despite their pivotal physiological and pathophys...

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Detalles Bibliográficos
Autores principales: Kim, S J, Li, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730412/
https://www.ncbi.nlm.nih.gov/pubmed/23846218
http://dx.doi.org/10.1038/cddis.2013.238