Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer

Activating mutation of KRas is a genetic alteration that occurs in the majority of pancreatic tumors and is therefore an ideal therapeutic target. The ability of reoviruses to preferentially replicate and induce cell death in transformed cells that express activated Ras prompted the development of a...

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Detalles Bibliográficos
Autores principales: Carew, J S, Espitia, C M, Zhao, W, Kelly, K R, Coffey, M, Freeman, J W, Nawrocki, S T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730429/
https://www.ncbi.nlm.nih.gov/pubmed/23868061
http://dx.doi.org/10.1038/cddis.2013.259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730429/
https://www.ncbi.nlm.nih.gov/pubmed/23868061
http://dx.doi.org/10.1038/cddis.2013.259

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