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T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone Metastases Establishment in a Mouse Model of Metastatic Breast Cancer
Bone metastases, present in 70% of patients with metastatic breast cancer, lead to skeletal disease, fractures and intense pain, which are all believed to be mediated by tumor cells. Engraftment of tumor cells is supposed to be preceded by changes in the target tissue to create a permissive microenv...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730734/ https://www.ncbi.nlm.nih.gov/pubmed/23935856 http://dx.doi.org/10.1371/journal.pone.0068171 |
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author | Monteiro, Ana Carolina Leal, Ana Carolina Gonçalves-Silva, Triciana Mercadante, Ana Carolina T. Kestelman, Fabiola Chaves, Sacha Braun Azevedo, Ricardo Bentes Monteiro, João P. Bonomo, Adriana |
author_facet | Monteiro, Ana Carolina Leal, Ana Carolina Gonçalves-Silva, Triciana Mercadante, Ana Carolina T. Kestelman, Fabiola Chaves, Sacha Braun Azevedo, Ricardo Bentes Monteiro, João P. Bonomo, Adriana |
author_sort | Monteiro, Ana Carolina |
collection | PubMed |
description | Bone metastases, present in 70% of patients with metastatic breast cancer, lead to skeletal disease, fractures and intense pain, which are all believed to be mediated by tumor cells. Engraftment of tumor cells is supposed to be preceded by changes in the target tissue to create a permissive microenvironment, the pre-metastatic niche, for the establishment of the metastatic foci. In bone metastatic niche, metastatic cells stimulate bone consumption resulting in the release of growth factors that feed the tumor, establishing a vicious cycle between the bone remodeling system and the tumor itself. Yet, how the pre-metastatic niches arise in the bone tissue remains unclear. Here we show that tumor-specific T cells induce osteolytic bone disease before bone colonization. T cells pro-metastatic activity correlate with a pro-osteoclastogenic cytokine profile, including RANKL, a master regulator of osteoclastogenesis. In vivo inhibition of RANKL from tumor-specific T cells completely blocks bone loss and metastasis. Our results unveil an unexpected role for RANKL-derived from T cells in setting the pre-metastatic niche and promoting tumor spread. We believe this information can bring new possibilities for the development of prognostic and therapeutic tools based on modulation of T cell activity for prevention and treatment of bone metastasis. |
format | Online Article Text |
id | pubmed-3730734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37307342013-08-09 T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone Metastases Establishment in a Mouse Model of Metastatic Breast Cancer Monteiro, Ana Carolina Leal, Ana Carolina Gonçalves-Silva, Triciana Mercadante, Ana Carolina T. Kestelman, Fabiola Chaves, Sacha Braun Azevedo, Ricardo Bentes Monteiro, João P. Bonomo, Adriana PLoS One Research Article Bone metastases, present in 70% of patients with metastatic breast cancer, lead to skeletal disease, fractures and intense pain, which are all believed to be mediated by tumor cells. Engraftment of tumor cells is supposed to be preceded by changes in the target tissue to create a permissive microenvironment, the pre-metastatic niche, for the establishment of the metastatic foci. In bone metastatic niche, metastatic cells stimulate bone consumption resulting in the release of growth factors that feed the tumor, establishing a vicious cycle between the bone remodeling system and the tumor itself. Yet, how the pre-metastatic niches arise in the bone tissue remains unclear. Here we show that tumor-specific T cells induce osteolytic bone disease before bone colonization. T cells pro-metastatic activity correlate with a pro-osteoclastogenic cytokine profile, including RANKL, a master regulator of osteoclastogenesis. In vivo inhibition of RANKL from tumor-specific T cells completely blocks bone loss and metastasis. Our results unveil an unexpected role for RANKL-derived from T cells in setting the pre-metastatic niche and promoting tumor spread. We believe this information can bring new possibilities for the development of prognostic and therapeutic tools based on modulation of T cell activity for prevention and treatment of bone metastasis. Public Library of Science 2013-07-18 /pmc/articles/PMC3730734/ /pubmed/23935856 http://dx.doi.org/10.1371/journal.pone.0068171 Text en © 2013 Monteiro et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Monteiro, Ana Carolina Leal, Ana Carolina Gonçalves-Silva, Triciana Mercadante, Ana Carolina T. Kestelman, Fabiola Chaves, Sacha Braun Azevedo, Ricardo Bentes Monteiro, João P. Bonomo, Adriana T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone Metastases Establishment in a Mouse Model of Metastatic Breast Cancer |
title | T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone
Metastases Establishment in a Mouse Model of Metastatic Breast
Cancer |
title_full | T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone
Metastases Establishment in a Mouse Model of Metastatic Breast
Cancer |
title_fullStr | T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone
Metastases Establishment in a Mouse Model of Metastatic Breast
Cancer |
title_full_unstemmed | T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone
Metastases Establishment in a Mouse Model of Metastatic Breast
Cancer |
title_short | T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone
Metastases Establishment in a Mouse Model of Metastatic Breast
Cancer |
title_sort | t cells induce pre-metastatic osteolytic disease and help bone
metastases establishment in a mouse model of metastatic breast
cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730734/ https://www.ncbi.nlm.nih.gov/pubmed/23935856 http://dx.doi.org/10.1371/journal.pone.0068171 |
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