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The Length of the Shortest Telomere as the Major Determinant of the Onset of Replicative Senescence
The absence of telomerase in many eukaryotes leads to the gradual shortening of telomeres, causing replicative senescence. In humans, this proliferation barrier constitutes a tumor suppressor mechanism and may be involved in cellular aging. Yet the heterogeneity of the senescence phenotype has hinde...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Genetics Society of America
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730915/ https://www.ncbi.nlm.nih.gov/pubmed/23733785 http://dx.doi.org/10.1534/genetics.113.152322 |