Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway

BACKGROUND: Y294002 (LY) is a potent inhibitor of phosphatidylinositol 3-kinases (PI3Ks); however, biological applications of LY are limited by its poor solubility and pharmacokinetic profile. This study aimed at developing LY-loaded surfactant-free poly(lactic-co-glycolic acid) (PLGA) nanoparticles...

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Detalles Bibliográficos
Autores principales: Hou, Chia-Cheng, Tsai, Tsung-Lin, Su, Wen-Pin, Hsieh, Hsing-Pang, Yeh, Chen-Sheng, Shieh, Dar-Bin, Su, Wu-Chou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731111/
https://www.ncbi.nlm.nih.gov/pubmed/23940416
http://dx.doi.org/10.2147/IJN.S47208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731111/
https://www.ncbi.nlm.nih.gov/pubmed/23940416
http://dx.doi.org/10.2147/IJN.S47208

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