Regulation of A1 by OX40 Contributes to CD8(+) T Cell Survival and Anti-Tumor Activity

The TNFR family member OX40 (CD134) is critical for optimal clonal expansion and survival of T cells. However, the intracellular targets of OX40 in CD8 T cells are not fully understood. Here we show that A1, a Bcl-2 family protein, is regulated by OX40 in effector CD8 T cells. In contrast to wild-ty...

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Detalles Bibliográficos
Autores principales: Lei, Fengyang, Song, Jianyong, Haque, Rizwanul, Haque, Mohammad, Xiong, Xiaofang, Fang, Deyu, Croft, Michael, Song, Jianxun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731243/
https://www.ncbi.nlm.nih.gov/pubmed/23936461
http://dx.doi.org/10.1371/journal.pone.0070635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731243/
https://www.ncbi.nlm.nih.gov/pubmed/23936461
http://dx.doi.org/10.1371/journal.pone.0070635

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